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CJM court reserves judgement on Dow contention of jurisdiction

Bhopal: The court of judicial magistrate first class (JMFC), Vidhan Maheshwari, reserved judgement on the contention of lawyers appearing for US chemical giant M/s Dow Chemical that it has no jurisdiction to summon a company based in the USA for trial in connection with the Bhopal gas disaster criminal case. A battery of 15 lawyers appearing for Dow Chemical including senior council Siddartha Luthara and Ravindra Shiravastava argued for over 5 hours how Dow Chemical could not have been summoned by the court based at Bhopal on an application moved by an NGO -Bhopal Group for Information & Action (BGIA). Advocate Avi Singh argued the case for BGIA and Siyaram Meena for the prosecution agency CBI. The BGIA had sought the presence of Dow Chemical in the Bhopal gas disaster criminal case contending that it had taken over Union Carbide Corporation (UCC), a proclaimed absconder in the case. In this way, Dow Chemical is shielding an absconder in the case, BGIA contended. Dow Chemical had appeared in the case for the first time last year after the 7th summons issued by the Bhopal court was served on the company through the US justice department. However, senior counsel Ravindra Shrivastava, who led the battery of lawyers appearing for Dow Chemical in the first hearing, refused to accept jurisdiction of the Bhopal court to summon Dow Chemical and said their presence should not be deemed as Dow Chemical accepting the jurisdiction of the court and submitting to it. The arguments on the issue of jurisdiction have continued in the last 3 hearings. After prolonged arguments on Saturday, the JMFC court reserved its judgement over the issue for January 18. We also published the following articles recently IISER Bhopal Researchers develop material to break down chemical warfare agents like Mustard GasResearchers at IISER Bhopal have developed a new photocatalyst, UC-POP-Au, that absorbs the entire spectrum of light and shows great catalytic efficiency. This breakthrough allows for the detoxification of chemical warfare agents like mustard gas simulants. The photocatalyst has been tested on cotton cloth under direct sunlight and has demonstrated excellent performance in expediting photocatalysis. Furthermore, UC-POP-Au is reusable and can be used multiple times without significant loss in catalytic activity. This research opens up new possibilities in the development of advanced materials for harnessing light energy to break down toxic chemicals.106551041 SC to examine court jurisdiction in Mahua caseSolicitor general Tushar Mehta argued before the Supreme Court that internal proceedings of Lok Sabha should not be subject to judicial review in the case of TMC leader Mahua Moitra's expulsion. Mehta emphasized that Parliament has its own sovereignty and can manage disciplinary issues internally. The separation of powers under the Constitution would be violated if the judiciary interfered in the functioning of Parliament. The court agreed to examine the jurisdiction and scope of judicial review. Moitra's lawyer, Abhishek Manu Singhvi, highlighted the violation of natural justice in the proceedings against her.106528816 Chemical or organic? Your choice mattersThis article discusses the impact of chemicals on food quality and the loss of micro-nutrients. It highlights a study that found a significant decrease in calcium content in cabbage over the years. The Centre for Science and Environment (CSE) conducted lab testing and discovered a decline in macro and micro nutrients in various crops. Medical experts have started linking the deficiency of essential nutrients in food to the rise in certain diseases. The article also mentions the benefits of naturally grown food in terms of healing and restorative health.106610417

ATM agriculture requires imagination

I am standing on a sun-baked landscape, barren and desolate as far as the eye can see. This is Ananthapuramu district in Andhra Pradesh, where rain this year was less than normal and farmers missed the sowing season. But as I look down, I can see signs of crop life bursting. T Vijay Kumar, who heads the state government’s community-managed natural-farming programme called Rythu Sadhikara Samstha, explains that the crops are growing from pelletised seeds — in this method, farmers coat the seeds with materials like cow dung and ash, and then plant them in circles with minimal disturbance to the soil. These seeds can lie in the soil for 30-45 days, waiting for as little as 5-10 mm of rain to sprout. Another risk-mitigation measure is planting a variety of crops, from red gram to castor oil plant to beans. The women farmers tell me that this technique has allowed them to cultivate during a season that would have gone to waste. In our climate-risked times, when rainfall will become even more variable, this is the reworking of farm practices we desperately need. We then go on to visit more farmers practising what is called natural farming. I wanted to understand how different this practice is from what we know as organic or non-chemical farming. Field after field, we see a combination of trees and food crops. I can see arecanut, moringa tree (drumstick), and papaya on the farm boundaries, and vegetables like beetroot, spinach, and beans, all growing with millets, corn, and even lentils. Everything is growing in profusion, but without any order, or at least that is how it seems to me. But then Lakshma Naik, chief technology and innovation officer of Rythu Sadhikara Samstha, tells me there is an order to this cultivation. The objective is to build a web of plants so that this biodiversity can regenerate the soil structure with different fungi and bacteria. The objective is also to provide farmers income from diverse crops with different durations. Mr Naik calls this particular model ATM or Anytime Money. It’s a bonanza of crops, all grown using only natural fertilisers or bio-stimulants. What excites me is the incredible scale of this programme, which covers every district of Andhra Pradesh. The programme, initially called zero-budget farming, was started in 2015. Today, 800,000 farmers or 14 per cent of the state’s cultivators practise natural farming in some form. This is not the organic-farming method that I knew. In this agriculture, conventional science is turned upside down. The first principle of this method is that biodiversity is integral to building soil strength. This means that polycropping is not just a risk-mitigation method but also needed to improve the soil’s microbial life. The second principle, which again goes against what farm scientists tell us, is to not expose the soil to sunlight — in other words, keep the land covered with biomass at all times. This is then combined with the practice in which the soil is minimally disturbed or not tilled. All this is done to improve soil porosity and soil biodiversity, which then reduces water consumption and improves photosynthesis. Then comes the use of bio-stimulants, made from cow dung, urine, jaggery, and lentil flour. These trigger actions in the soil to improve productivity. As I understand, this practice is not much about plant science but about soil science. But this is why there is so much resistance to the idea of this kind of agriculture. It is different — organic agriculture is still largely about conventional practices but without chemicals. In this case, science promotes competition in the plants so that they can build soil reservoirs of fungi and bacteria and everything underneath we know little about. The question is why farmers are taking to natural farming and what it will take to make it even more popular. The answer to the first question is simple; it is economics that is driving the change. Farmers who practise natural farming tell me that their productivity matches that of their neighbours who practise conventional farming. But they spend next to nothing on seeds, pesticides, or fertilisers. Their water expenses are low. They use family labour, and in this way they earn double or more of what others do. They are also able to mitigate risk with multiple crops. The second question is difficult to answer. The fact is that there is no buy-in from the established agricultural paraphernalia. Scientists still view this agriculture as unproductive. The knowledge of its practice is not considered enough to support its extension. This is why today, in Andhra Pradesh, the real force behind the practice is not men but women. It is the village women’s self-help groups that are coming together to practise, to learn, and to propagate the idea. I come back inspired, but also sad to see how the business of science has lost the courage of imagination. This is where the gods are failing us.

Every 5 buildings should have open spaces: Experts

Lucknow: Make it mandatory to have open spaces for every five buildings, rejuvenate water bodies, and interlink them if possible to address issues like urban heat islands (UHIs) and urban flooding (waterlogging), which Lucknow is also facing. These were the suggestions given by experts at the 72nd National Town and Country Planners Conference on Saturday. These would create a greener and cooler city by preserving parks and recreational areas, said experts at the ongoing meet in the city. During a panel discussion, experts said UHIs occur when urban areas become much hotter than the surrounding rural areas due to the heat-absorbing nature of buildings and infrastructure. Rajneesh Sareen, director of the Centre of Science, emphasized the importance of having 10 square metres of open space per person, as recommended by the World Bank, to mitigate the UHI effect. He said research indicates that urban green spaces (UGSs) play a crucial role in combating UHIs. Dr. Rutul Joshi, an architect and urban planner, said that implementing these measures can make Lucknow a more sustainable and liveable city, improving air quality, public health, and the overall urban environment. To address urban flooding, VP Kulshrestha, general secretary of the Institute of Town Planners India, suggested upgrading drainage infrastructure. This includes expanding storm drains, revitalizing natural streams, and implementing decentralized storage solutions like retention ponds and green roofs. “Involving the community through awareness campaigns and local flood mitigation plans can help Lucknow build a future free from waterlogging issues,” he added.

Delhi-NCR Ended 2023 On A High Pollution Note: CSE Analysis

The year 2023’s winter months were a period when the region of Delhi-NCR slipped back into the abyss of high pollution levels — despite having seen a gradual long-term improvement in annual PM 2.5 concentrations since 2015-17. Particles are defined by their diametre for air quality regulatory purposes. Those with a diametre of 10 microns or less (PM10) are inhalable into the lungs and can induce adverse health effects. Fine particulate matter is defined as particles that are 2.5 microns or less in diametre (PM2. 5). The forward march towards cleaner air and clearer skies came to a grinding halt in 2023, says a new analysis by Centre for Science and Environment (CSE), partly due to meteorological factors. The region witnessed cleaner-than-usual summer and monsoon seasons, and much lower ingress of smoke from farm stubble fires in the northern states. But unusually low surface wind speed in winter meant that local pollution, which was already quite high, was trapped. This led to the spike in pollution levels. Says Anumita Roychowdhury, executive director, research and advocacy, CSE: “Due to the impact of the unusual winter levels, the overall annual concentrations plateaued and even worsened, undoing the gains of the long-term downward trend. "With the contribution of stubble burning to Delhi’s pollution going down this year, with more rains in November and less severe cold winter conditions, the annual level should have improved further. Instead, the worsening of meteorological conditions — lowering of wind speed — tilted the scale adversely simply because the local pollution was still very high. Delhi needs more aggressive emissions reduction steps to meet the national ambient air quality standard.” Avikal Somvanshi, senior programme manager, Urban Lab, CSE points out: “Interestingly, the summer and monsoon months in 2023 were unusually cleaner compared to the months in the previous years. But winter levels turned out to be one of the worst due to very slow surface wind speed. This impeded the dispersal of pollution and led to higher levels. "This trapping of local pollution from all sides made this winter exceptionally bad despite lesser smoke from farm fires. The meteorology also explains lower pollution peaks and relatively uniform bad air quality with minimal fluctuations in the PM2.5 concentration throughout the season.” The winter pollution analysis was carried out by CSE’s Urban Lab. The objective, says Somvanshi, has been “to understand the trend and the starting line of the onset of the winter pollution season in this region.” Key Highlights Of The CSE Analysis 2023’s annual average PM2.5 levels worse than that of 2022 — but not as high as it used to be: Delhi has been witnessing a gradual yet consistent decline in its annual PM2.5 levels since 2015-17, with 2020 being the only outlier due to massive disruption caused by pandemic lockdowns. But this downward movement stopped in 2023. Delhi’s PM2.5 annual average for 2023 (up till 29 December 2023) stood at 100.9 microgram per cubic metre (µg/m3). This was an increase of 2 per cent compared to the 2022 annual level, and was 6 per cent higher than an exceptionally clean 2020. However, the levels were not as high as they used to be earlier — the average of 2018-22 winters is higher than that of the winter of 2023. Winter condition has affected the 2023 trend — summer is getting progressively cleaner: In 2023, about 151 days met the National Ambient Air Quality Standard. This was similar to the 2021 trend and second only to 2020 (a lockdown year) when 174 days had met the standards. In 2022, only 117 days met the standard. Almost all of these cleaner days were observed during summer and monsoon seasons. There was a significant fall in the number of ‘good’ air quality days (when levels are 50 per cent below the standard) in 2023; this stood at 24 days compared to 41 in 2022. Meanwhile, in 2023, the number of days with PM2.5 concentration in the ‘very poor’ or ‘worse’ categories (as per the air quality index classification) stood at 107 days, including 24 with ‘severe’ levels (until 30 December 2023). In 2022, there were 106 ‘very poor’ or ‘worse’ days, but ‘severe’ days were just nine in number — this was less than half of that of 2023. Summer is cleaner, while winter is becoming worse: In 2023, the summer months (from March to June) were significantly less polluted (14-36 per cent) than the corresponding months in 2022. But the winter months of January, November and December were much more polluted in 2023 (12-34 per cent) compared to the months in 2022 (see corresponding graph in the complete report). The transition period including February, July, September and October does not show much change, which might be due to the fact that the monsoon months were already very clean. What Went Wrong In The Winter Of 2023? Though the number of days with ‘very poor’ and ‘severe’ PM2.5 concentration increased, peak pollution was down: Between 1 October and 29 December, there were only three days of ‘satisfactory’ air quality and zero days of ‘good’ air quality. There were more days of these categories in the same period in the previous two years. The number of ‘severe+’ days was the same as in the winters of 2019, 2020 and 2021, but the peak intensity was lower. The peak in 2023 was 349 µg/m3 and happened on 13 November (the day after Diwali). This is much lower than the peaks recorded in the previous years: in 2022, the peak was 401 µg/m3, while in 2019 it went up to 546 µg/m3. Highest number of smog episodes observed this season in last six winters: Delhi usually experiences two smog episodes (a smog episode is defined as at least three or more minimum continuous days with air quality in the ‘severe’ category) in the months of November and December. In 2023, there were three episodes by 24 December; on 30 December, Delhi was reeling under its third day of continuous ‘severe’ air quality, which was turning into the city’s fourth smog episode. This was the highest number of smog episodes observed in a season in last six winters. Overall, 2023 winter seems to have had the most consistently bad air compared to the last six winters, with minimal fluctuations in daily PM2.5 levels. Data indicates that it was the longest spell of ‘very poor’ or ‘worse’ air in last six years. Slow surface winds seem to be the main contributory factor to the winter trend: Farm stubble fire smoke is generally perceived to be the main contributor to heightened PM2.5 levels during the first half of the winter season. But in 2023, the number of fires in Punjab and Haryana were nearly identical to 2022’s number of incidences. In November 2023, the average surface wind speed in Delhi was 9.8 m/s, which was the lowest in the last six years. It was 21 per cent less than the wind speed in November of 2022. Somvanshi explains: “Low wind speed means that local pollution dispersion is horizontally restricted, while vertical dispersion is already restricted because of the winter inversion phenomenon. This trapping of local pollution from all sides has made this winter exceptionally bad despite lesser smoke from farm stubble fires. "This also explains low peaks and relatively uniform bad air quality with minimal fluctuations in PM2.5 concentration throughout the season. It must also be noted that heavy rains in November had insignificant impact on air quality.” Way Ahead Steps are required for clean fuel transition in all segments of industries, with stringent compliance with emissions targets and replacement of solid fuels in households and eateries. Action towards elimination of waste burning, with a comprehensive waste management system ensuring 100 per cent segregated collection, material recovery and remediation of legacy waste and stringent measures in the construction sector.

Pb, Hry farm fires dipped, but NCR saw pollution spike: CSE analysis

Bathinda: Despite cleaner-than-usual summer and monsoon seasons, and lesser smoke from farm fires in Punjab and Haryana, Delhi and the national capital region (NCR) slipped back into the abyss of high pollution levels in the winter months of 2023. This was due to the low surface wind speed which impeded the dispersal of pollution and led to higher levels. This trapping of local pollution from all sides made this winter exceptionally bad, revealed the new analysis by Centre for Science and Environment (CSE) released on Thursday. Smoke from stubble fire is generally perceived to be the main contributor to heightened PM 2.5 levels during the first half of the winter season, however, in 2023, the number of farm fires in Punjab and Haryana were less than those recorded in 2022. The analysis stated that despite seeing a gradual long-term improvement in annual PM 2.5 concentrations since 2015-17, the forward march towards cleaner air came to a grinding halt in 2023 partly due to meteorological factors. Data from both MODIS and VIIRS satellites shows that the contribution of farm fires to PM 2.5 in November 2023 only adds up to 1.48 tonne (calculated on the basis of SAFAR’s decision support system estimates) which was lowest in the last six years. Winters in 2023 also recorded the maximum rainfall in the last six years, and the cold conditions were less severe than usual. Avikal Somvanshi, senior programme manager, Urban Lab, CSE, said: “All these factors should have led to a cleaner winter. But this was undone by the lack of surface winds.” He said low wind speed meant that local pollution dispersion was horizontally restricted, while vertical dispersion was already restricted because of the winter inversion phenomenon. This trapping of local pollution from all sides made this winter exceptionally bad despite lesser smoke from farm stubble fires, he said, adding that: “This also explains low peaks and relatively uniform bad air quality with minimal fluctuations in PM 2.5 concentration throughout the season. It must also be noted that heavy rains in November had insignificant impact on air quality.” Anumita Roychowdhury, executive director, research and advocacy, CSE, said: “This winter is a lasting reminder of the fact that Delhi, despite succeeding to bend the long-term pollution curve downward over the last few years, has not achieved deeper cuts in emissions to sustain a more aggressive reduction for meeting air quality standards and prevent winter spikes.”

CSE Study : दिल्ली में पिछली सर्दी में 34 फीसदी ज्यादा रहा प्रदूषण, गर्मियां रहीं बेहतर

सांसों में घुलता जहर बच्चों और बुजुर्गों के साथ-साथ हर उम्र के लोगों को परेशान कर रहा है। सेंटर फॉर साइंस एंड एनवायरनमेंट (सीएसई) के अनुसार 2023 में जाड़ों के महीने जनवरी, नवंबर और दिसंबर 2022 की तुलना में 12 से 34% ज्यादा प्रदूषित रहे। मार्च से जून 2023 में गर्मियों के महीने 2022 में इन महीनों की तुलना में कहीं ज्यादा साफ रहे। आंकड़े बताते हैं कि इस दौरान प्रदूषण 14 से 36% कम रहा। फरवरी, जुलाई, सितंबर और अक्तूबर को देखें तो उस दौरान वायु गुणवत्ता में बहुत ज्यादा अंतर नहीं देखा गया। मानसून के महीने भी सामान्य से अधिक साफ रहे। दिल्ली-एनसीआर में प्रदूषण के महीन कणों पीएम 2.5 के स्तर में गिरावट का जो सिलसिला 2015-17 में शुरू हुआ था वो 2023 में सर्दियों के दौरान थम गया। विश्लेषण में इसके लिए मौसम संबंधी कारकों को जिम्मेदार माना है। ब्यूरो गर्मी-मानसून में ज्यादा साफ रहा मौसम दिल्ली-एनसीआर में असामान्य परिस्थितियों के चलते प्रदूषण का स्तर ऊंचा रहा। 2023 के दौरान गर्मी व मानसून का मौसम सामान्य से कहीं ज्यादा साफ रहा। सर्दियों में इस साल उत्तरी राज्यों में पराली जलाने से होने वाला प्रदूषण पिछले वर्षों की तुलना में कम रहा। हवा असामान्य रूप से सुस्त थी। नवंबर 2023 के दौरान दिल्ली में हवा की रफ्तार 9.8 मीटर/सेकंड थी, जो छह वर्षों में सबसे कम रही। इससे इस क्षेत्र में सर्दियों के दौरान प्रदूषण के स्तर में इजाफा दर्ज किया गया। सीएसई के अनुसार, दिल्ली में 2015-17 के बाद से पीएम 2.5 के स्तर में गिरावट आई है। हालांकि यह प्रवृत्ति 2023 में रुक गई। इस दौरान पीएम 2.5 का वार्षिक औसत स्तर 100.9 माइक्रोग्राम प्रति घन मीटर दर्ज किया गया।

2023 ended on a high pollution note, finds CSE analysis of winter air pollution levels in Delhi-NCR

Factors like reduced contribution from stubble burning, November rains and milder winters were undone by low wind speed The gradual, long-term improvement in the annual levels of ultrafine particulate matter (PM) 2.5 in the Delhi-National Capital Region (NCR) air since 2015-17 halted in winter 2023, an analysis by Delhi-based think tank Centre for Science and Environment (CSE) found. Meteorological conditions, combined with high local pollution, were at fault. The summer and monsoon seasons were cleaner than usual, the CSE analysis said. The ingress of smoke from farm stubble fires in the northern states was also lower this time. But unusually low surface wind speeds in winter meant that local pollution, which was already quite high, was trapped, leading to a spike in pollution levels. The impact of the unusual winter levels caused the overall annual levels to plateau and even worsen, undoing the gains of the long-term downward trend, the analysis showed. “This winter is a lasting reminder of the fact that Delhi, despite succeeding to bend the long-term pollution curve downward over the last few years, has not achieved deeper cuts in emissions to sustain a more aggressive reduction for meeting air quality standards and prevent winter spikes,” said Anumita Roychowdhury, executive director, research and advocacy, CSE. Delhi’s PM2.5 annual average for 2023 (through December 29, 2023) stood at 100.9 microgrammes per cubic metre (µg/m3). This was an increase of 2 per cent compared to the 2022 annual level and was 6 per cent higher than an exceptionally clean 2020 due to lockdowns imposed over the COVID-19 pandemic. However, the levels were not as high as they were previously — the average of the 2018-22 winters is higher than the winter of 2023. The long-term three-year average trend among the five oldest Continuous Ambient Air Quality Monitoring Stations (CAAQMS) stations of the city (ITO, IHBAS, Mandir Marg, Punjabi Bagh and RK Puram) also showed a similar pattern. This 2021-23 average is nearly 3 per cent higher than its 2020-22 counterpart. CSE also discovered that winter conditions influenced pollution trends in 2023, and that summers are becoming cleaner. Summer months (March to June) in 2023 were significantly less polluted (14-36 per cent) than the same months in 2022. However, the winter months of January, November, and December were significantly more polluted in 2023 (12-34 per cent) than in 2022. The number of days with ‘very poor’ and ‘severe’ PM2.5 concentrations increased, CSE found. However, peak pollution was down: Between October 1 and December 29, there were only three days of ‘satisfactory’ air quality and zero days of ‘good’ air quality. There were more days in these categories in the same period in the previous two years. The peak intensity of ‘severe+’ days was lower, even though the number of days was the same as in the winters of 2019, 2020 and 2021. The 2023 peak was 349 g/m3 and occurred on November 13 (the day after Diwali). This is significantly lower than previous years’ peaks: in 2022, the peak was 401 g/m3, while in 2019, it increased to 546 g/m3. Delhi also witnessed six smog episodes (at least three or more minimum continuous days with air quality in the ‘severe’ category) in the season, when it usually witnesses around two such episodes. This was the highest in a single season in the previous six winters. Farm stubble fire smoke is widely regarded as the primary source of elevated PM2.5 levels during the first half of the winter season. However, the number of fires in Punjab and Haryana in 2023 was nearly identical to the number of incidents in 2022. The contribution of fires to PM2.5 in November 2023 was the lowest in the last six years; 2023 winter also recorded the maximum rainfall in the last six years, and the cold conditions were less severe than usual. The lack of surface winds undid the hopes of any clean winter. “Low wind speed means that local pollution dispersion is horizontally restricted, while vertical dispersion is already restricted because of the winter inversion phenomenon. This trapping of local pollution from all sides has made this winter exceptionally bad despite lesser smoke from farm stubble fires,” said Avikal Somvanshi, senior programme manager, Urban Lab, CSE.

PM2.5 Levels Increased In Delhi In 2023, The First Time Since 2015-17: Study

The concentration of Particulate matter (PM2.5) in the air in Delhi showed an increase in 2023, compared to the previous year, a new study has said. According to the analysis by the Centre for Science and Environment (CSE) of publicly available data for Delhi-NCR, there was a 2% increase in PM2.5 concentration in 2023 than in 2022. Progress made in seven years halted The annual concentration of PM2.5 in Delhi in 2022 was 101 microgramS per cubic metre, which increased to 100.9 microgramS per cubic metre in 2023. CSE said that the gradual long-term improvement in annual PM2.5 levels since 2015-17 was halted in 2023. What happened in 2023 This occurred despite cleaner-than-usual summer and monsoon seasons and significantly reduced intrusion of smoke from farm fires in northern states. However, this winter witnessed unusually low surface wind speeds, trapping high local pollution levels. Due to the impact of unusual winter levels, the overall annual levels have plateaued and worsened, reversing the gains of the long-term downward trend, the CSE said. Annual PM2.5 trends in Delhi Delhi had been experiencing a consistent decline in its annual PM2.5 levels since 2015-17, with 2020 being the only outlier due to pandemic lockdowns. The average annual PM2.5 concentrations were 115.8 microgrammes per cubic metre in 2018, 109.2 in 2019, 95.1 in 2020, 106.2 in 2021, 98.6 in 2022, and 100.9 in 2023, according to the data. What is PM2.5? Particulate Matter (PM2.5) describes fine inhalable particles with diameters that are generally 2.5 micrometers and smaller.

New class of antibiotics that can kill drug-resistant bacteria finally on the horizon?

Zosurabalpin was found to have potent, selective activity against Acinetobacter strains, including drug-resistant strains of Carbapenem-resistant A baumannii F Hoffmann-La Roche AG, commonly known as Roche, a Swiss multinational healthcare company, has identified a new class of antibiotics that is active against gram-negative bacteria. This news becomes especially relevant as there has not been a single novel class of antibiotic against such bacteria on the market for the last five decades (since 1968). Zosurabalpin, the antibiotic in question, was found to have potent and selective activity against Acinetobacter strains of pneumonia and sepsis, including drug-resistant strains of Carbapenem-resistant A baumannii (CRAB), in mice. The medicine is currently being tested on humans under clinical development. Two more molecules belonging to the same family of macrocyclic peptides are also under development. CRAB is classified as a priority 1 (critical) pathogen by the World Health Organization (WHO), alongside two other drug-resistant forms of bacteria – Pseudomonas aeruginosa and Enterobacteriaceae. Priority pathogens is a catalogue of 12 families of bacteria released by WHO, that pose the greatest threat to human health. According to the 2019 report of the Centers for Disease Control and Prevention on antibiotic resistance, CRAB was responsible for killing 700 people in 2017 and added about $281 million in healthcare costs. This bacterium typically causes infections in the blood, urinary tract, lungs and wounds in people who have been cared for in healthcare settings, are very sick, are immunocompromised or require invasive medical devices, like urinary or bloodstream catheters or ventilators. Gram-negative bacteria are extraordinarily difficult to kill because their cytoplasmic membrane is surrounded by an outer membrane that blocks the entry of most antibiotics. The impenetrable nature of the outer membrane is due to the presence of a large, amphipathic glycolipid called lipopolysaccharide (LPS) in its outer leaflet. Through a series of experiments published in the journal Nature on January 3, 2023, Roche and Harvard University scientists described how the new class of antibiotics works by interrupting construction of the bacteria’s outer membrane by targeting the LPS transport machine in Acinetobacter. “New antibiotics directed against the world’s highest priority bacteria, like Acinetobacter baumannii, require novel development paths,” said Michael Lobritz, head of infectious diseases, Roche Pharma Research and Early Development (pRED), in an article released by the company. In July 2023, researchers from the Delhi-based think tank Centre for Science and Environment published a story in Down To Earth on the current status of antibiotic innovation. With very few antibiotics under development, an analysis of the clinical pipeline of 15 high-earning companies revealed that only a very small percentage (1.3 per cent) of molecules were being developed for treating bacterial infections, while a majority of the molecules were for other disease areas like cancer, immunology, among others. Only four companies out of 15 were involved in developing antibacterial candidates, Roche being one of them. This large gap can be attributed to most of the big pharmaceutical companies leaving the antibiotic development space a few decades ago with the complaint that antibiotic innovation is not as rewarding as developing drugs for other lucrative areas like oncology. The issue, however, is that these companies exited the critical antibiotic business even though they are making record profits in other disease areas. This is of great concern as with more and more antibiotics becoming ineffective due to the rising issue of antimicrobial resistance (AMR), innovation of new drugs is critical and the need of the hour. In 2019, about five million deaths worldwide were estimated to be associated with AMR. It can also impact food security, livelihood, universal health coverage and the attainment of several sustainable development goals. “Antimicrobial resistance is called a ‘silent pandemic’, and over the next 30 years, it is projected to claim more lives than those taken by cancer today,” added Michael in the Roche article. We are a voice to you; you have been a support to us. Together we build journalism that is independent, credible and fearless. You can further help us by making a donation. This will mean a lot for our ability to bring you news, perspectives and analysis from the ground so that we can make change together. https://www.downtoearth.org.in/news/health/new-class-of-antibiotics-that-can-kill-drug-resistant-bacteria-finally-on-the-horizon--93712

CSE Study : दिल्ली में पिछली सर्दी में 34 फीसदी ज्यादा रहा प्रदूषण, गर्मियां रहीं बेहतर

सांसों में घुलता जहर बच्चों और बुजुर्गों के साथ-साथ हर उम्र के लोगों को परेशान कर रहा है। सेंटर फॉर साइंस एंड एनवायरनमेंट (सीएसई) के अनुसार 2023 में जाड़ों के महीने जनवरी, नवंबर और दिसंबर 2022 की तुलना में 12 से 34% ज्यादा प्रदूषित रहे। मार्च से जून 2023 में गर्मियों के महीने 2022 में इन महीनों की तुलना में कहीं ज्यादा साफ रहे। आंकड़े बताते हैं कि इस दौरान प्रदूषण 14 से 36% कम रहा। फरवरी, जुलाई, सितंबर और अक्तूबर को देखें तो उस दौरान वायु गुणवत्ता में बहुत ज्यादा अंतर नहीं देखा गया। मानसून के महीने भी सामान्य से अधिक साफ रहे। दिल्ली-एनसीआर में प्रदूषण के महीन कणों पीएम 2.5 के स्तर में गिरावट का जो सिलसिला 2015-17 में शुरू हुआ था वो 2023 में सर्दियों के दौरान थम गया। विश्लेषण में इसके लिए मौसम संबंधी कारकों को जिम्मेदार माना है। ब्यूरो गर्मी-मानसून में ज्यादा साफ रहा मौसम दिल्ली-एनसीआर में असामान्य परिस्थितियों के चलते प्रदूषण का स्तर ऊंचा रहा। 2023 के दौरान गर्मी व मानसून का मौसम सामान्य से कहीं ज्यादा साफ रहा। सर्दियों में इस साल उत्तरी राज्यों में पराली जलाने से होने वाला प्रदूषण पिछले वर्षों की तुलना में कम रहा। हवा असामान्य रूप से सुस्त थी। नवंबर 2023 के दौरान दिल्ली में हवा की रफ्तार 9.8 मीटर/सेकंड थी, जो छह वर्षों में सबसे कम रही। इससे इस क्षेत्र में सर्दियों के दौरान प्रदूषण के स्तर में इजाफा दर्ज किया गया। सीएसई के अनुसार, दिल्ली में 2015-17 के बाद से पीएम 2.5 के स्तर में गिरावट आई है। हालांकि यह प्रवृत्ति 2023 में रुक गई। इस दौरान पीएम 2.5 का वार्षिक औसत स्तर 100.9 माइक्रोग्राम प्रति घन मीटर दर्ज किया गया।

Improvement in Delhi's annual PM2.5 levels since 2015-17 halted in 2023, says CSE report Read more at:https://www.magzter.com/stories/newspaper/Millennium-Post-Delhi/IMPROVEMENT-IN-DELHIS-ANNUAL-PM25-LEVELS-SINCE-201517-HALTED-IN-2023-SAYS-CSE-REPORT

Delhi-NCR recorded the longest spell of ‘very poor’ or worse air quality and the maximum number of smog episodes in November and December 2023 in the last six years, according to a new analysis. The Centre for Science and Environment (CSE), an independent think-tank that analysed pollution data for Delhi-NCR, said the gradual long-term improvement in annual PM2.5 levels since 201517 halted in 2023. This occurred despite cleaner-than-usual summer and monsoon seasons and significantly reduced intrusion of smoke from farm fires in northern states. However, this winter witnessed unusually low surface wind speeds, Read more at:https://www.magzter.com/stories/newspaper/Millennium-Post-Delhi/IMPROVEMENT-IN-DELHIS-ANNUAL-PM25-LEVELS-SINCE-201517-HALTED-IN-2023-SAYS-CSE-REPORT

Winter months in Delhi-NCR to be 34% more polluted by 2023: CSE

The Center for Science and Environment (CSE) has disclosed in its recent study that the pollution levels during the winter months of 2023, specifically January, November, and December, were 12 to 34 percent higher compared to the same period in 2022. Consequently, the winter season of 2023 experienced significantly increased pollution.